Iron Regulatory Protein 2

A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.

Also Known As:

IRE-BP2; IREB2 Protein; IRP-2 RNA-binding protein; IRP2 Protein; Iron-Responsive-Element Binding Protein 2; IRP 2 RNA binding protein; RNA-binding protein, IRP-2

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Lyases: 659
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 269
        Aconitate Hydratase: 290
        Iron Regulatory Protein 2: 46
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - RNA-Binding Proteins: 3439
      - Iron Regulatory Protein 2: 46
    - Iron-Binding Proteins: 176
      - Nonheme Iron Proteins
        Iron-Sulfur Proteins: 44
        Iron Regulatory Protein 2: 46
  - Nucleoproteins: 1892
    - RNA-Binding Proteins: 3439
      - Iron Regulatory Protein 2: 46
  - Metalloproteins: 169
    - Iron-Binding Proteins: 176
      - Nonheme Iron Proteins
        Iron-Sulfur Proteins: 44
        Iron Regulatory Protein 2: 46
  - Iron-Regulatory Proteins: 152
    - Iron Regulatory Protein 2: 46

Thomas Mariani Selected Research

Thomas Mariani Research Topics

Disease

Drug/Important Bio-Agent (IBA)